ftsY

signal recognition particle

locus: BSU_15950

pI: 5.08

mw: 36.19 kDa

protein length: 329 aa

gene length: 990 bp

function: protein secretion

product: signal recognition particle

essential: yes

synonyms: srb

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,670,140 → 1,671,129

Phenotypes of a mutant

• essential [Pubmed|28189581]

The protein

Protein family

• GTP-binding SRP family (with [protein|BB6F5D7463EF96E2C6344D0BC30A227C5E3B5817|FlhF] and [protein|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|Ffh], according to UniProt)

Structure

• [PDB|2XXA] (complex [protein|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|Ffh]-[protein|D519765BF5261E48512CE86245BD7B733F188D4A|FtsY]-[protein|097C817A5A3E31F73F6ABC4AA95852A64E43A057|Scr] RNA, from ''E. coli'') [Pubmed|21330537]

[SW|Localization]

• cell membrane, peripheral, via N-terminal lipid-binding domain [Pubmed|19414018]

Expression and Regulation

Operons

• genes: [gene|D519765BF5261E48512CE86245BD7B733F188D4A|ftsY]
  description: [Pubmed|11021934]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|11021934], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|11021934], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]

  regulatory mechanism

  • [protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|GerE]: activation, [Pubmed|11021934], in [regulon|19228BAD44E6DA3DE908DC390FDF628C18D94E65|GerE regulon]

  regulation

  • expressed during vegetative growth and during sporulation in the mother cell ([protein|search|SigK], [protein|search|GerE]) [Pubmed|11021934]

• genes: [gene|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|rnc]-[gene|0136394A52759CEEDD8DE074ED74033C6FFB8435|smc]-[gene|D519765BF5261E48512CE86245BD7B733F188D4A|ftsY]
  description: [Pubmed|11021934]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|11021934], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]

  regulation

  • expressed during vegetative growth and during sporulation in the mother cell ([protein|search|SigK], [protein|search|GerE]) [Pubmed|11021934]

References

Reviews

• 25212246,27890920

Original publications

• 16705751,15995216,11021934,21330537,23563142,21255212,27355662,19414018,28189581