pheA [Mon Feb 01 2016 11:06:48 GMT+0100 (CET)]

prephenate dehydratase

locus: BSU27900

pI: 5.00

mw: 31.00 kDa

function: biosynthesis of phenylalanine

product: prephenate dehydratase

essential: no

ec: 4.2.1.51

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

Gene

Coordinates on the chromosome (coding sequence): 2,851,283 -> 2,852,140

The protein

Catalyzed reaction/ biological activity

• Prephenate = phenylpyruvate H₂O CO₂ (according to Swiss-Prot)

Effectors of protein activity

• subject to feedback inhibtion by phenylalanine [Pubmed|4956345]

Expression and Regulation

Operon

• ''[SW|spo0B]-[protein|search|obg]-[protein|search|yszB]-[protein|search|pheA]'' [Pubmed|22383849]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|2537815]

Additional information

• subject to feedback inhibtion by phenylalanine [PubMed|4956345]

Biological materials

Mutant

• 1A617 ( ''pheA''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A617&Search=1A617 BGSC]

References

• 19258532,2537815,4956345