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murE [Tue Dec 29 2015 17:33:31 GMT+0100 (CET)]
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murE [Tue Dec 29 2015 17:33:31 GMT+0100 (CET)]

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase
locus
BSU15180
pI
5.00
mw
54.00 kDa
function
peptidoglycan precursor biosynthesis
product
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-
meso-2,6-diaminopimelate synthetase
essential
yes
ec
6.3.2.13
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|essential genes]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,586,330 -> 1,587,814

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP UDP-N-acetylmuramoyl-L-alanyl-D-glutamate meso-2,6-diaminoheptanedioate = ADP phosphate UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diamino-heptanedioate (according to Swiss-Prot)
  • Protein family

  • MurE subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|2WTZ] (from ''Mycobacterium tuberculosis'', 35% identity, 50% similarity) [Pubmed|19945347]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|murE]-[protein|search|mraY]-[protein|search|murD]-[SW|spoVE]-[protein|search|murG]-[protein|search|murB]-[SW|divIB]-[protein|search|ylxW]-[protein|search|ylxX]-[protein|search|sbp]'' [Pubmed|1391053]
  • Regulation

  • expressed during vegatative growth [Pubmed|1391053]
  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • References

  • 8436954,18063720,8436954,11948165,1391053