Sec-independent membrane protein translocase, essential for SigG activity at stage III, involved in the assembly of the SpoIIIAH-SpoIIQ complex
function
membrane insertion of proteins and protein secretion
product
membrane protein translocase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|protein secretion], [SW|sporulation/ other], [SW|membrane proteins]Gene
Coordinates on the chromosome (coding sequence)
4,213,823 -> 4,214,608
The protein
Catalyzed reaction/ biological activity
membrane protein translocase, facilitates insertion of [SW|SpoIIIAE] into the membrane [Pubmed|18485064]Protein family
YidC/Oxa1/Alb3 family [Pubmed|20800571,21194367,15802250]Paralogous protein(s)
[SW|YidC2], one of the two proteins has to be present for viability [Pubmed|17114254][SW|Localization]
membrane [Pubmed|18763711][SW|Interactions]
the active form is a dimer [Pubmed|25133632][SW|SpoIIIAE]-[SW|SpoIIIJ] [Pubmed|18820020][SW|SpoIIIJ]-[protein|search|MifM] [Pubmed|22864117]Expression and Regulation
Operon
''[SW|spoIIIJ]-[protein|search|jag]'' [Pubmed|1487728][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1487728]Labs working on this gene/protein
[SW|Richard Losick], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ homepage][SW|Adriano Henriques], Lisbon, Portugal [http://www.itqb.unl.pt/research/biology/microbial-development homepage]References
Reviews
22688815,20800571,21194367,15802250,25947384 Original publications
18485064,12813085,18820020,1487728,23852076,18763711,17114254,11889108,15995216,12586834,19717609,19779460,22864117,24443530,25133632,25313395,25359772,25855636 
