polX [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

DNA polymerase X, involved in DNA repair, generates adaptive mutations by error-prone processing of A/P sites

locus: BSU28590

pI: 5.31

mw: 63.00 kDa

function: DNA repair

product: DNA polymerase X

essential: no

ec: 2.7.7.7

synonyms: yshC

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination]

Gene

Coordinates on the chromosome (coding sequence): 2,923,314 -> 2,925,026

The protein

Catalyzed reaction/ biological activity

• template-dependent DNA polymerase, fills single nucleotide gaps [Pubmed|18938175]
• has intrinsic 3'-5' exonuclease activity for resecting unannealed 3'-termini in gapped DNA substrates [Pubmed|18776221]
• has intrinsic apurinic/apyrimidinic (AP) endonuclease activity [Pubmed|20974932]

Protein family

• DNA polymerase X family

[SW|Interactions]

• monomeric [Pubmed|18938175]

Labs working on this gene/protein

• [SW|Margarita Salas], Madrid, Spain [http://www.cbm.uam.es/mkfactory.esdomain/webs/CBMSO/plt_LineasInvestigacion.aspx?IdObjeto=28 link]

References

Reviews

• 22933559

Original publications

• 20974932,18938175,18776221,22844091,24914186