ahpC [Mon Jul 11 2016 18:44:22 GMT+0200 (CEST)]

alkyl hydroperoxide reductase (small subunit)

locus: BSU40090

pI: 4.00

mw: 20.00 kDa

function: resistance against peroxide stres

product: alkyl hydroperoxide reductase (small subunit)

essential: no

ec: 1.11.1.15

synonyms: perR

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue]

[SW|Categories] containing this gene/protein

• [SW|resistance against oxidative and electrophile stress], [SW|phosphoproteins], [SW|most abundant proteins]

This gene is a member of the following [SW|regulons]

• [SW|PerR regulon]

Gene

Coordinates on the chromosome (coding sequence): 4,118,950 -> 4,119,513

The protein

Catalyzed reaction/ biological activity

• 2 R'-SH ROOH = R'-S-S-R' H₂O ROH (according to Swiss-Prot)

Protein family

• ahpC/TSA family (according to Swiss-Prot)

Paralogous protein

• [SW|AhpA]

Modification

• phosphorylated on ser/ thr/ tyr [Pubmed|16493705]

Structure

• [PDB|1WE0] (from ''Amphibacillus xylanus'', 78% identity, 88% similarity) [Pubmed|15770647]

[SW|Interactions]

• [SW|AhpC]-[SW|AhpF] [Pubmed|15581580]

Expression and Regulation

Operon

• ''[protein|search|ahpC]-[protein|search|ahpF]'' [Pubmed|8932314]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8932314]

Regulation

• induced by H2O2 ([protein|search|PerR]) [Pubmed|11532148]

Regulatory mechanism

• [protein|search|PerR]: transcription repression [Pubmed|11532148]

Additional information

• belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

References

• 11532148,15378759,8932314,8932315,11532148,16493705,15581580,15770647