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sigV [2019-01-04 13:10:34]
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sigV [2019-01-04 13:10:34]

[SW|RNA polymerase] ECF-type [SW|sigma factor] SigV, required for resistance to lytic enzymes
locus
BSU27120
pI
9.04
mw
19.57 kDa
protein length
166 aa Sequence Blast
gene length
498 bp Sequence Blast
function
resistance to lytic enzymes
product
[SW|RNA polymerase] ECF-type [SW|sigma factor] SigV
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]

    • Gene

    Coordinates
    2,769,850 → 2,770,350

    Phenotypes of a mutant

  • increased sensitivity to lysozyme, this can be suppressed by overexpression of'' [gene|E97C7A219DB059BB634E893CC355A28324C87ADB|oatA]'' [Pubmed|21856855]

    • The protein

    Protein family

  • ECF subfamily (according to Swiss-Prot)

    • Effectors of protein activity

  • activity is controlled by the interaction with [protein|ED1DDA187692683D9862EC0E858B80CD56C48045|RsiV], proteolytic degradation of [protein|ED1DDA187692683D9862EC0E858B80CD56C48045|RsiV] releases active [protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|SigV] [Pubmed|23687273]

    • Additional information

  • Expression of the [SW|SigV regulon] in increased in ''[gene|7A606B8E952AE8CA4F9A62008BA4B156725BB5B5|ugtP]'' mutants [Pubmed|22362028]

    • Biological materials

    Mutant

  • MGNA-A144 (sigV::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/144 NBRP B. subtilis, Japan]
  • 1A907 ( ''sigV''::''kan''), [Pubmed|15838020], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A907&Search=1A907 BGSC]
  • BKE27120 (Δ[gene|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCAATAAAGGGCTCCT, downstream forward: _UP4_TTGACGAAGGAGGATCTTTC
  • BKK27120 (Δ[gene|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCAATAAAGGGCTCCT, downstream forward: _UP4_TTGACGAAGGAGGATCTTTC

    • labs

  • [SW|Thomas Wiegert], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas Wiegert-Dateien/Thomas Wiegert.html Homepage]

    • References

    Reviews

  • 24921931,26901131

    • Original publications

  • 14993308,16274938,17675383,19745567,22362028,23687273,20817771,21926231,21856855,26399770,29069433,30020925