2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, third step in the MEP pathway of isoprenoid biosynthesis
function
MEP pathway of isoprenoid biosynthesis
product
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|biosynthesis of lipids], [SW|general stress proteins (controlled by SigB)], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|SigB regulon], [SW|SigM regulon]Gene
Coordinates on the chromosome (coding sequence)
109,789 -> 110,487
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
CTP 2-C-methyl-D-erythritol 4-phosphate = diphosphate 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol (according to Swiss-Prot) Protein family
ispD family (according to Swiss-Prot)Structure
[PDB|5DDT] [Pubmed|27821871][PDB|5DDV] [Pubmed|27821871]Expression and Regulation
Operon
''[protein|search|yacL]-[protein|search|ispD]-[protein|search|ispF]'' [Pubmed|10482513][SW|Sigma factor]
[protein|search|SigB] [Pubmed|15805528], [protein|search|SigM] [Pubmed|17434969]Regulation
induced by stress ([protein|search|SigB]) [Pubmed|15805528]References
15805528,10482513,17458547,17434969,23840410,21766403,27821871 
