pyrG [Mon Aug 31 2015 13:57:19 GMT+0200 (CEST)]

CTP synthase (NH3, glutamine)

locus: BSU37150

pI: 5.16

mw: 59.00 kDa

function: pyrimidine biosynthesis

product: CTP synthase (NH3, glutamine)

essential: yes

ec: 6.3.4.2

synonyms: ctrA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

syns: ctrA

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of nucleotides], [SW|essential genes]

Gene

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP + UTP + NH₃ = ADP + phosphate + CTP (according to Swiss-Prot)

Protein family

• CTP synthase family (according to Swiss-Prot)

Structure

• [PDB|1VCM] (from ''Thermus thermophilus'', 52% identity, 70% similarity) [Pubmed|15296735]

Expression and Regulation

Operon

• ''pyrG'' [Pubmed|2457578]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|15252202]

Regulation

• repressed by cytidine nucleotides ([SW|RNA switch]) [Pubmed|11544212]

Regulatory mechanism

• [SW|RNA switch]: transcription (termination in the presence of cytidine nucleotides) [Pubmed|11544212]

References

Reviews

• 21334966,18535147

Original publications

• 8206849,17302819,15252202,11544212,1709162,12426364,17158658,2457578