SubtiBank SubtiBank
pyrG
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pyrG

CTP synthase (NH3, glutamine)
locus
BSU37150
pI
5.16
mw
59.55 kDa
protein length
535 aa Sequence Blast
gene length
1605 bp Sequence Blast
function
pyrimidine biosynthesis
product
CTP synthase (NH3, glutamine)
essential
yes
ec
6.3.4.2
synonyms
ctrA

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    3,810,693 → 3,812,300

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP + UTP + NH3 = ADP + phosphate + CTP (according to Swiss-Prot)
  • Protein family

  • CTP synthase family (according to Swiss-Prot)
  • Structure

  • [PDB|1VCM] (from ''Thermus thermophilus'', 52% identity, 70% similarity) [Pubmed|15296735]
  • Expression and Regulation

    Operons

    genes
    [gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG]
    description
    [Pubmed|2457578]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|15252202], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [regulon|RNA switch|RNA switch]: termination, in [regulon|RNA switch|RNA switch]
  • regulation

  • repressed by cytidine nucleotides ([SW|RNA switch]) [Pubmed|11544212]
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    additional information

  • the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
  • References

    Reviews

  • 21334966,18535147
  • Original publications

  • 8206849,17302819,15252202,11544212,1709162,12426364,17158658,2457578,28652344,26883633