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holA [Mon Jan 18 2016 17:14:07 GMT+0100 (CET)]
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holA [Mon Jan 18 2016 17:14:07 GMT+0100 (CET)]

DNA polymerase III, delta subunit, part of the clamp-loader complex and the replisome
locus
BSU25560
pI
6.00
mw
40.00 kDa
function
DNA replication
product
DNA polymerase III, delta subunit
essential
yes
synonyms
yqeN

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA replication], [SW|essential genes]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,636,096 -> 2,637,139

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • required for bacteriophage SPP1 replication [Pubmed|23268446]
  • [SW|Domains]

  • domain I: aa 1 - 143, RecA-like fold [Pubmed|23525462]
  • domain II: aa 144 - 214, four alpha helices [Pubmed|23525462]
  • domain III: aa 215 - 339, seven alpha helices [Pubmed|23525462]
  • Structure

  • [PDB|3ZH9] [Pubmed|23525462]
  • [SW|Localization]

  • Nucleoid (Mid-cell) [Pubmed|16479537]
  • [SW|Interactions]

  • [protein|search|DnaX](3)-[protein|search|HolA]-[protein|search|HolB], the clamp-loader complex [Pubmed|23525462]
  • part of the [SW|replisome]: [protein|search|PolC]-[protein|search|HolA]-[protein|search|HolB]-[protein|search|DnaX]-[protein|search|DnaN]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|SsbA]-[protein|search|DnaE]-[protein|search|PriA]-[protein|search|DnaB] [Pubmed|20122408]
  • [protein|search|DnaE]-[protein|search|HolA] [Pubmed|23563155]
  • [SW|HolA]-[SW|YmaF] [Pubmed|12060778]
  • References

  • 16479537,20122408,23525462,23268446,23563155