SubtiBank SubtiBank
nrdF
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nrdF

ribonucleoside-diphosphate reductase (major subunit)
locus
BSU17390
pI
4.66
mw
38.22 kDa
protein length
329 aa Sequence Blast
gene length
987 bp Sequence Blast
function
synthesis of deoxyribonucleoside triphosphates
product
ribonucleoside-diphosphate reductase (major subunit)
essential
yes
ec
1.17.4.1
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.5|Biosynthesis/ acquisition of nucleotides/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    1,871,089 → 1,872,078

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • 2'-deoxyribonucleoside diphosphate thioredoxin disulfide H2O = ribonucleoside diphosphate thioredoxin (according to Swiss-Prot)
  • required for stationary-phase mutagenesis [Pubmed|27920297]
  • Protein family

  • ribonucleoside diphosphate reductase small chain family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|08B733574DC7B8D044033EBB94124D470A0FBE19|YosP]
  • [SW|Cofactors]

  • Mn(2 ) [Pubmed|21561096]
  • dimanganic-tyrosyl radical (MnIII2-Y•) cofactor [Pubmed|24401092]
  • Structure

  • [PDB|4DR0] [Pubmed|22443445]
  • Expression and Regulation

    Operons

    genes
    [gene|1EA0595C74359A36B9161CFD531CA894C5E66E25|nrdI]-[gene|3B68CE8E9A35997B45E437A316996D585E43B76B|nrdE]-[gene|CD2D14FE9C10544E7C350167EBDBD941B898051D|nrdF]-[gene|8C2A08A8395B72CCC9D03A8154602B8F3B77A1AA|ymaB]
    description
    [Pubmed|16885274]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|16885274], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: activation, [Pubmed|16885274], in [regulon|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD regulon]
  • [protein|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|NrdR]: repression, (predicted) [Pubmed|15949864], in [regulon|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|NrdR regulon]
  • [protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR]: transcription repression, [Pubmed|27920297], in [regulon|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR regulon]
  • regulation

  • expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|16885274]
  • additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|ymzA]' and '[protein|search|nrdI]' [PubMed|20525796]
  • view in new tab

    genes
    [gene|93FA602438546FD6201FAB5BD19DB5DEB5965E48|ymzA]-[gene|1EA0595C74359A36B9161CFD531CA894C5E66E25|nrdI]-[gene|3B68CE8E9A35997B45E437A316996D585E43B76B|nrdE]-[gene|CD2D14FE9C10544E7C350167EBDBD941B898051D|nrdF]-[gene|8C2A08A8395B72CCC9D03A8154602B8F3B77A1AA|ymaB]
    description
    [Pubmed|22383849]
    view in new tab

    Labs working on this gene/protein

  • [SW|Elisabeth Härtig], Braunschweig, Germany [http://www.tu-braunschweig.de/ifm/abt/jahn/groups/bs Homepage]
  • References

    Reviews

  • 17229208
  • Original Publications

  • 16885274,8969495,24401092,23402532,22443445,21561096,15949864,27920297,28624879