function
arginine utilization
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.4|Utilization of arginine/ ornithine][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][SW|Categories] containing this gene/protein
[SW|utilization of amino acids]This gene is a member of the following [SW|regulons]
[SW|AhrC regulon], [SW|CodY regulon], [SW|RocR regulon], [SW|SigL regulon], [SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
4,141,711 -> 4,142,601
The protein
Catalyzed reaction/ biological activity
L-arginine H2O = L-ornithine urea (according to Swiss-Prot) Protein family
arginase family (according to Swiss-Prot)Modification
phosphorylated on Ser-68 [Pubmed|20509597]Structure
[PDB|2CEV] (from ''Bacillus caldevelox'', 71% identity) [Pubmed|10196128]Expression and Regulation
Operon
''[protein|search|rocD]-[protein|search|rocE]-[protein|search|rocF]'' [Pubmed|7540694][SW|Sigma factor]
[protein|search|SigL] [Pubmed|7540694]Regulation
induced by arginine ([protein|search|RocR], [protein|search|AhrC]) [Pubmed|7540694]repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]Regulatory mechanism
[protein|search|RocR], [protein|search|AhrC]: transcription activation [Pubmed|7540694][SW|Spo0A]: transcription repression [Pubmed|14651647][protein|search|CodY]: transcription repression [Pubmed|12618455]Biological materials
Mutant
GP655, aphA3, available in the [SW|Stülke] labReferences
12618455,20509597,14651647,12618455,7540694,23625224,10196128 
