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yfnI [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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yfnI [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

polyglycerolphosphate lipoteichoic acid synthase, general stress protein, major secreted protein, required for survival at low temperature (4°C)
locus
BSU07260
pI
5.00
mw
73.00 kDa
function
biosynthesis of lipoteichoic acid
product
minor lipoteichoic acid synthetase
essential
no
synonyms
yetP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.3|Biosynthesis of lipoteichoic acid]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.2|Biosynthesis of lipoteichoic acid]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue]

    • [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigM regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    796,314 -> 798,233

    Phenotypes of a mutant

  • induction of [protein|search|SigM] and [protein|search|SigX] activities [Pubmed|23103977]
  • more sensitive to nisin [Pubmed|23980836]
  • increased conjugation of ICEBs1 [Pubmed|25069588]

    • The protein

    Protein family

  • LTA synthase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|LtaS], [protein|search|YqgS], [protein|search|YvgJ]

    • Modification

  • phosphorylation on (Thr-311 OR Ser-312) [Pubmed|17218307]

    • [SW|Localization]

  • extracellular (signal peptide) [Pubmed|18957862]

    • Expression and Regulation

    Operon

  • ''yfnI'' (according to [http://dbtbs.hgc.jp/COG/prom/yfnI.html DBTBS])

    • [SW|Sigma factor]

  • [protein|search|SigM] [Pubmed|17434969]

    • Additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''yfnI'' [Pubmed|27120414]

    • Biological materials

    Mutant

  • SM-NB (''yfnI-spc''), available in [SW|Anne Galinier]'s and [SW|Boris Görke]'s labs
  • GP1390 ''yfnI::spc'', available in [SW|Jörg Stülke]'s lab
  • GP1397 ''yfnI::ermC'', available in [SW|Jörg Stülke]'s lab

    • References

    Reviews

  • 21388439,21255102

    • Original publications

  • 17434969,18957862,17218307,19229300,21255105,23103977,23980836,25069588,27120414