qoxB [Mon Feb 01 2016 10:35:53 GMT+0100 (CET)]

cytochrome aa3 quinol oxidase (subunit I)

locus: BSU38160

pI: 8.00

mw: 73.00 kDa

function: respiration

product: cytochrome aa3 quinol oxidase (subunit I)

essential: no

ec: 1.10.3.-

synonyms: ipa-38d

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|respiration], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|stringent response]

Gene

Coordinates on the chromosome (coding sequence): 3,915,319 -> 3,917,268

Phenotypes of a mutant

• inactivation of ''[protein|search|qoxB]'' restores beta-lactam resistance in a ''[protein|search|sigM]'' mutant [Pubmed|22211522]
• inactivation of ''qoxB'' facilitates without a wall (due to reduction of oxidative stress) [Pubmed|26051891]

The protein

Catalyzed reaction/ biological activity

• Ubiquinol-8 O₂ = Ubiquinone-8 H₂O (according to Swiss-Prot)

Protein family

• heme-copper respiratory oxidase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|CtaD]

[SW|Cofactors]

• Cu(B) [Pubmed|10837475]

[SW|Localization]

• cell membrane [Pubmed|18763711]

Expression and Regulation

Operon

• ''[protein|search|qoxA]-[protein|search|qoxB]-[protein|search|qoxC]-[protein|search|qoxD]'' [Pubmed|1316894]

Regulation

• [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

References

• 11073895,1316894,20351111,10551842,18763711,21821766,10837475,24779955,22211522,26196462,26051891