yngH [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

methylcrotonoyl-CoA carboxylase

locus: BSU18240

pI: 7.00

mw: 48.00 kDa

function: mother cell metabolism, leucine utilization

product: methylcrotonoyl-CoA carboxylase, subunit

essential: no

ec: 6.4.1.4

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.9|Utilization of branched-chain amino acids]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]

[SW|Categories] containing this gene/protein

• [SW|utilization of amino acids], [SW|sporulation proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigE regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,953,181 -> 1,954,515

The protein

Catalyzed reaction/ biological activity

• ATP biotin-carboxyl-carrier protein CO₂ = ADP phosphate carboxybiotin-carboxyl-carrier protein (according to Swiss-Prot)

[SW|Cofactors]

• biotin

Structure

• [PDB|1ULZ] (biotin carboxylase subunit of pyruvate carboxylase from Aquifex aeolicus, 52% identity) [Pubmed|14993673]

[SW|Interactions]

• [protein|search|YngH]-[protein|search|YngE] [Pubmed|19935659]

Expression and Regulation

Operon

• ''[protein|search|yngJ]-[protein|search|yngI]-[protein|search|yngH]-[SW|yngHB]-[protein|search|yngG]-[protein|search|yngF]-[protein|search|yngE]'' [Pubmed|12662922]

[SW|Sigma factor]

• [protein|search|SigE] [Pubmed|15699190,12662922]

Regulation

• expressed during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|15699190,12662922]

References

• 15699190,12662922,19935659,14993673