You are currently viewing an outdated version of
SubtiWiki.
Please use
the newest version!
pyrC [Mon Aug 31 2015 13:54:13 GMT+0200 (CEST)]
function
pyrimidine biosynthesis
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides]This gene is a member of the following [SW|regulons]
[SW|PyrR regulon]The protein
Catalyzed reaction/ biological activity
(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate (according to Swiss-Prot)Protein family
Type 2 subfamily (according to Swiss-Prot)Paralogous protein(s)
[protein|search|PucH]Structure
[PDB|3GRI] (from ''Staphylococcus aureus subsp. aureus mw2'', 60% identity, 72% similarity)Expression and Regulation
Operon
''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1709162]Regulation
induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]Regulatory mechanism
[protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]References
