cell wall hydrolase with both amidase and endopeptidase activities, required for dissolution of the septal cell wall
product
cell wall hydrolase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 6|Groups of genes] → [category|SW 6.11|Efp-dependent proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell wall/ other], [SW|sporulation proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigE regulon], [SW|SigF regulon], [SW|Efp-dependent proteins]Gene
Coordinates on the chromosome (coding sequence)
2,633,237 -> 2,634,442
The protein
Catalyzed reaction/ biological activity
removes the stem peptides from the cell wall and cleaves the cross-links between them [Pubmed|20159959]required for proper localization of [SW|SpoIIQ] (together with [SW|SpoIID]) [Pubmed|23834622]Effectors of protein activity
activity is stimulated by interaction with [SW|SpoIID] [Pubmed|20159959][SW|Localization]
cell membrane [Pubmed|20159959]the complex of [SW|SpoIID], [SW|SpoIIM], and [SW|SpoIIP] localizes at the leading edge of the mother cell engulfing membrane and is essential and rate limiting for membrane migration [Pubmed|20382772,12502745][SW|Interactions]
[SW|SpoIID]-[SW|SpoIIP] [Pubmed|20159959][SW|SpoIIP]-[SW|SpoIIM] [Pubmed|17376078]Expression and Regulation
Operon
''[SW|spoIIP]-[protein|search|yqxA]'' [Pubmed|7836306], ''[protein|search|gpr]-[SW|spoIIP]'' [Pubmed|16497325][SW|Sigma factor]
''[SW|spoIIP]'': [protein|search|SigE] [Pubmed|7836306]''[protein|search|gpr]'':[protein|search|SigF] [Pubmed|16497325]Regulation
expressed early during sporulation ([protein|search|SigE],[protein|search|SigF]) [Pubmed|16497325,7836306]Additional information
[protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]References
Reviews
Original publications
16497325,17376078,15882622,11886548,15752199,20159959,20382772,23834622,23859254,12502745 
