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polY1 [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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polY1 [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

translesion synthesis (TLS-) DNA polymerase Y1, important for stationary phase mutagenesis, promotes efficient replisome progression through lagging-strand genes, thereby reducing potentially detrimental breaks and single-stranded DNA at these loci
locus
BSU23870
pI
9.95
mw
46.00 kDa
function
generation of mutations in stationary phase
product
translesion synthesis (TLS-) DNA polymerase Y1
essential
no
ec
2.7.7.7
synonyms
yqjH

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA repair/ recombination]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,482,269 -> 2,483,513

    Phenotypes of a mutant

  • reduced UV-induced mutagenesis [Pubmed|12644484]
  • The protein

    Catalyzed reaction/ biological activity

  • Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
  • Protein family

  • DNA polymerase type-Y family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [SW|PolY2], [protein|search|UvrX], [protein|search|YozK]-[protein|search|YobH]
  • [SW|Localization]

  • cytoplasm (homogeneous)
  • [SW|Interactions]

  • [SW|PolY1]-[protein|search|DnaN] (required for untargeted mutagenesis) [Pubmed|15469515]
  • [protein|search|PolA]-[SW|PolY1]-[protein|search|DnaN] [Pubmed|16045613]
  • Expression and Regulation

    Operon

  • ''[SW|polY1]-[protein|search|gndA]'' (according to [http://dbtbs.hgc.jp/COG/prom/yqjHI.html DBTBS])
  • Regulation

  • constitutively expressed [Pubmed|15469515]
  • Biological materials

    Mutant

  • GP1111 (spc), available in [SW|Stülke] lab
  • References

    Reviews

  • 22933559
  • Original publications

  • 12644484,15469515,16045613,19924481,23686288,25713353