ribosomal protein L16,binding of L16 to the 50S subunit is required for the stimulation of RbgA GTPase activity, for release of RbgA from the ribosome, and for the conversion of the intermediate to the complete 50S subunit
product
ribosomal protein L16
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|stringent response]Gene
Coordinates on the chromosome (coding sequence)
139,500 -> 139,934
Phenotypes of a mutant
essential [Pubmed|23002217,12682299]The protein
Protein family
[SW|ribosomal protein] L16P family (according to Swiss-Prot)Additional information
the protein is significantly underrepresented in 45S assembly intermediates that accumulate upon depletion of [protein|search|RbgA] [Pubmed|24335279,23700310]Expression and Regulation
Operon
''[protein|search|rpsJ]-[protein|search|rplC]-[protein|search|rplD]-[protein|search|rplW]-[protein|search|rplB]-[protein|search|rpsS]-[protein|search|rplV]-[protein|search|rpsC]-[protein|search|rplP]-[protein|search|rpmC]-[protein|search|rpsQ]-[protein|search|rplN]-[protein|search|rplX]-[protein|search|rplE]-[protein|search|rpsN]-[protein|search|rpsH]-[protein|search|rplF]-[protein|search|rplR]-[protein|search|rpsE]-[protein|search|rpmD]-[protein|search|rplO]'' [Pubmed|9371452][SW|Sigma factor]
[protein|search|SigA] two promoters, about 140bp and 200bp upstream of the start codon [Pubmed|9371452]Regulation
[protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]References
8635744,9371452,19653700,11948165,8635744,23002217,23700310,24335279 
