SubtiBank SubtiBank
rnz
An ordered knock out library of all non-essential genes in B. subtilis is now available at Addgene. Information on ordering a copy can be found here. See Koo et al. 2017 for details about library construction.

rnz

RNase Z
locus
BSU23840
pI
5.80
mw
33.87 kDa
protein length
307 aa Sequence Blast
gene length
921 bp Sequence Blast
function
processing of CCA-less tRNA precursors
product
endoribonuclease Z
essential
yes
ec
3.1.26.11
synonyms
yqjK

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.2|Endoribonucleases]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    2,478,006 → 2,478,929

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs (according to Swiss-Prot)
  • 3' end maturation of tmRNA [Pubmed|25402410]
  • Protein family

  • [SW|RNase] Z family (according to Swiss-Prot)
  • Structure

  • [PDB|2FK6] (in complex with tRNA-Thr) [Pubmed|22940585], [PDB|1Y44]
  • Expression and Regulation

    Operons

    genes
    [gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz]
    description
    (according to [http://dbtbs.hgc.jp/COG/prom/yqjK.html DBTBS]) null
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    Labs working on this gene/protein

  • [SW|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage]
  • References

    Reviews

  • 19215776,17599240,25878039
  • Original Publications

  • 17005971,12941704,15654328,16518398,22940585,25402410,24022488