ycgT [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

NADPH:ferredoxin oxidoreductase

locus: BSU03270

pI: 5.00

mw: 36.00 kDa

function: unknown

product: NADPH:ferredoxin oxidoreductase

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.4|Electron transport/ other/ based on similarity]

[SW|Categories] containing this gene/protein

• [SW|electron transport/ other]

This gene is a member of the following [SW|regulons]

• [SW|Fur regulon]

Gene

Coordinates on the chromosome (coding sequence): 352,858 -> 353,868

The protein

Catalyzed reaction/ biological activity

• 2 reduced ferredoxin NADP H = 2 oxidized ferredoxin NADPH (according to Swiss-Prot)

Protein family

• ferredoxin--NADP reductase type 2 family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YumC]

[SW|Cofactors]

• FAD [Pubmed|25826316]

Additional information

• The gene is annotated in KEGG as an ortholog of thioredoxin reductase (NADPH) EC 1.8.1.9. In MetaCyc the protein is marked as “similar to thioredoxin
• reductase”. No EC annotation is available in Swiss-Prot. No literature/experimental evidence supporting the annotation is available. [Pubmed|19935659]

Expression and Regulation

Operon

• ''ycgT'' (according to [http://dbtbs.hgc.jp/COG/prom/ycgT.html DBTBS])

Regulation

• induced under conditions of iron starvation ([protein|search|Fur]) [Pubmed|16672620]

Regulatory mechanism

• [protein|search|Fur]: transcription repression [Pubmed|16672620]

Additional information

• the mRNA is very stable (half-life > 15 min) [Pubmed|12884008]

Biological materials

Mutant

• GP1851 (aphA3), available in [SW|Jörg Stülke]'s lab
• GP1852 (cat), available in [SW|Jörg Stülke]'s lab

References

• 12884008,16672620,25826316