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nth [Mon Aug 31 2015 13:55:15 GMT+0200 (CEST)]
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nth [Mon Aug 31 2015 13:55:15 GMT+0200 (CEST)]

apurinic/apyrimidinic endonuclease , endonuclease III, removes abasic sites during base excision repair
locus
BSU22340
pI
9.28
mw
24.00 kDa
function
DNA repair
product
endonuclease III
essential
no
synonyms
jooB, ypoB

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.2|A/P endonucleases]
  • syns
    jooB, ypoB

    [SW|Categories] containing this gene/protein

  • [SW|DNA repair/ recombination]
  • Gene

    Phenotypes of a mutant

  • the mutant is sensititive to exposure to H2O2 [Pubmed|21954439]
  • The protein

    Catalyzed reaction/ biological activity

  • The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate (according to Swiss-Prot)
  • Effectors of protein activity

  • activity is stimulated by untwisting of the DNA (by [protein|search|DnaD], [protein|search|Hbs], or [protein|search|YonN]) [Pubmed|21954439]
  • Structure

  • [PDB|1P59] (complex with DNA, Geobacillus stearothermophilus)
  • Expression and Regulation

    Operon

  • ''[protein|search|dnaD]-[protein|search|nth]'' [Pubmed|21954439]
  • Regulation

  • constitutively expressed [Pubmed|21954439]
  • expression is transiently increased after treatment with H2O2 [Pubmed|21954439]
  • References

    Reviews

  • 22933559
  • Original publications

  • 12840008,21954439,24914186