liaF [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

inhibitor of LiaS kinase activity

locus: BSU33100

pI: 9.00

mw: 26.00 kDa

function: control of LiaR activity

product: negative effector of LiaS

essential: no

synonyms: yvqF

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|transcription factors and their control], [SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|LiaR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,396,114 -> 3,396,839

The protein

Catalyzed reaction/ biological activity

• inhibitor of [protein|search|LiaS] kinase activity, maintains [protein|search|LiaS] in the phosphatase state in the absence of the stress signal [Pubmed|23279150]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|14651641]
• ''[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|16816187]

[SW|Sigma factor]

• ''liaI'': [protein|search|SigA] [Pubmed|15273097]
• ''liaG'': [protein|search|SigA] [Pubmed|16816187]

Regulation

• ''[protein|search|liaI]'': induced by bacitracin and rhamnolipids ([protein|search|LiaR]) [Pubmed|16816187,22092710]
• ''[protein|search|liaI]'': repressed during logarithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]
• ''[protein|search|liaG]'': constitutive

Regulatory mechanism

• [protein|search|LiaR]: transcription activation [Pubmed|16816187]

References

Reviews

• 27344142

Original publications

• 19164152,20639339,15273097,17660417,16816187,15101989,17660417,16816187,23279150,20817675,22092710,23326432