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yxaM

similar to antibiotic resistance protein

locus: BSU_39930

pI: 8.31

mw: 44.59 kDa

protein length: 399 aa

gene length: 1200 bp

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.14|Resistance against toxins/ antibiotics/ based on similarity]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 4,101,166 → 4,102,365

The protein

Protein family

• [SW|major facilitator superfamily] (according to UniProt)

[SW|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|787BB72119DB1321A8281D7C46FED28CAEDBC97C|yxbB]-[gene|88B01CC87394AEE693A98574F9343EBF99F0D60E|yxbA]-[gene|A15368CD02487EBC1AF999FED34672E38167BCB2|yxnB]-[gene|9446D9C88CBBBC5A08495D8AA49A92A9F47F2C9B|asnH]-[gene|BF0E188249161B3CC24D223FDD48B820EBED8F55|yxaM]
  description: [Pubmed|10746760]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|20185509], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|12618455], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]
  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|15101989], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]

  regulation

  • repressed by glucose (8-fold) [Pubmed|12850135]

Biological materials

Mutant

• MGNA-B688 (yxaM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1687 NBRP B. subtilis, Japan]
• BKE39930 (Δ[gene|BF0E188249161B3CC24D223FDD48B820EBED8F55|yxaM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE39930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCGGAAAACGAATAAAAGA, downstream forward: _UP4_TAAATGTTTTGTATCACAGT
• BKK39930 (Δ[gene|BF0E188249161B3CC24D223FDD48B820EBED8F55|yxaM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK39930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCGGAAAACGAATAAAAGA, downstream forward: _UP4_TAAATGTTTTGTATCACAGT

References

• 10746760,10498721,12618455,15101989