yybP

membrane protein, may be involved in manganese detoxification

locus: BSU_40560

pI: 4.24

mw: 15.83 kDa

protein length: 148 aa

gene length: 447 bp

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 4,169,166 → 4,169,612

The protein

Structure

• [PDB|3LLL] (from the mouse, 28% identity) [pubmed|20471395]

[SW|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|BD3A3D84AD3A21B634B8EBAF684B690FE02BD857|yybP]
  description: [Pubmed|25794618]

  regulatory mechanism

  • [regulon|yybP-ykoY motif|yybP-ykoY motif]: antitermination, in the presence of the ligand Mn²⁺ [Pubmed|25794618], in [regulon|yybP-ykoY motif|yybP-ykoY motif]

  regulation

  • induced in the presence of Mn²⁺ ([SW|yybP-ykoY motif]) [Pubmed|25794618]
  • the [SW|RNA switch] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]

Biological materials

Mutant

• MGNA-B838 (yybP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1837 NBRP B. subtilis, Japan]
• BKE40560 (Δ[gene|BD3A3D84AD3A21B634B8EBAF684B690FE02BD857|yybP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE40560 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTCAGCCCCCTCATCG, downstream forward: _UP4_TAAGAAAAAGCATCCCGACG
• BKK40560 (Δ[gene|BD3A3D84AD3A21B634B8EBAF684B690FE02BD857|yybP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK40560 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTCAGCCCCCTCATCG, downstream forward: _UP4_TAAGAAAAAGCATCCCGACG

References

• 15096624,25794618,25794619,20471395,29794222