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21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.
hutI [Mon Oct 10 2016 10:54:57 GMT+0200 (CEST)]
categories[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 188.8.131.52|Utilization of histidine]
[SW|Categories] containing this gene/protein[SW|utilization of amino acids]
This gene is a member of the following [SW|regulons][SW|CcpA regulon], [SW|CodY regulon], [SW|HutP regulon]
Coordinates on the chromosome (coding sequence)
4,045,245 -> 4,046,510
Catalyzed reaction/ biological activity
(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate H2O = N-formimidoyl-L-glutamate H (according to Swiss-Prot)
Protein familyhutI family (according to Swiss-Prot)
[SW|Localization]cytoplasm (according to Swiss-Prot)
Expression and Regulation
[SW|Sigma factor][protein|search|SigA] [Pubmed|8071225]
Regulationrepressed by glucose ([protein|search|CcpA]) [Pubmed|8071225]induced by histidine ([protein|search|HutP]) [Pubmed|8071225]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8682780]
Regulatory mechanism[protein|search|CcpA]: transcription repression [Pubmed|8071225][protein|search|CodY]: transcription repression [Pubmed|8682780][protein|search|HutP]: transcriptional antitermination at a protein-dependent [SW|RNA switch] located between ''[protein|search|hutP]'' and ''[protein|search|hutH]'' [Pubmed|8071225]