SubtiBank SubtiBank
hutI [Mon Oct 10 2016 10:54:57 GMT+0200 (CEST)]
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hutI [Mon Oct 10 2016 10:54:57 GMT+0200 (CEST)]

imidazolone-5-propionate hydrolase
locus
BSU39370
pI
5.00
mw
45.00 kDa
function
histidine utilization
product
imidazolone-5-propionate hydrolase
essential
no
ec
3.5.2.7
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.5|Utilization of histidine]
  • [SW|Categories] containing this gene/protein

  • [SW|utilization of amino acids]
  • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|CodY regulon], [SW|HutP regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    4,045,245 -> 4,046,510

    The protein

    Catalyzed reaction/ biological activity

  • (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate H2O = N-formimidoyl-L-glutamate H (according to Swiss-Prot)
  • Protein family

  • hutI family (according to Swiss-Prot)
  • Structure

  • [PDB|2BB0]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|hutP]-[protein|search|hutH]-[protein|search|hutU]-[protein|search|hutI]-[protein|search|hutG]-[protein|search|hutM]'' [Pubmed|10746760]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8071225]
  • Regulation

  • repressed by glucose ([protein|search|CcpA]) [Pubmed|8071225]
  • induced by histidine ([protein|search|HutP]) [Pubmed|8071225]
  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8682780]
  • Regulatory mechanism

  • [protein|search|CcpA]: transcription repression [Pubmed|8071225]
  • [protein|search|CodY]: transcription repression [Pubmed|8682780]
  • [protein|search|HutP]: transcriptional antitermination at a protein-dependent [SW|RNA switch] located between ''[protein|search|hutP]'' and ''[protein|search|hutH]'' [Pubmed|8071225]
  • References

    Reviews

  • 22933560
  • Original publications

  • 10746760,8071225,8682780,10217782,16990261,27711543