SubtiBank SubtiBank
pupG [Mon Aug 31 2015 13:55:25 GMT+0200 (CEST)]
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pupG [Mon Aug 31 2015 13:55:25 GMT+0200 (CEST)]

purine nucleoside phosphorylase
locus
BSU23490
pI
4.86
mw
28.00 kDa
function
purine salvage and interconversion
product
purine nucleoside phosphorylase
essential
no
ec
2.4.2.1
synonyms
punA, pnp, yqkO

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • syns
    punA, pnp, yqkO

    [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|phosphoproteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate (according to Swiss-Prot) RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate (according to Swiss-Prot)
  • Protein family

  • PNP/MTAP phosphorylase family (according to Swiss-Prot) polyribonucleotide nucleotidyltransferase family (according to Swiss-Prot)
  • Modification

  • phosphorylation on Ser-28 [Pubmed|17218307]
  • [SW|Localization]

  • secreted (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|drm]-[protein|search|pupG]'' [Pubmed|10537218]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|10537218]
  • Regulation

  • induced in the presence of nucleosides (deoxyribose 5-phosphate and ribose 5-phosphate act as molecular inducers) [Pubmed|10537218]
  • subject to carbon catabolite repression ([protein|search|CcpA]) [Pubmed|22900538,10537218]
  • Regulatory mechanism

  • [protein|search|CcpA]: transcription repression [Pubmed|22900538]
  • References

  • 10537218,22900538,17218307