malS [Mon Feb 01 2016 10:12:39 GMT+0100 (CET)]

malate dehydrogenase (decarboxylating), forms a transhydrogenation cycle with YtsJ for balancing of NADPH

locus: BSU29880

pI: 4.00

mw: 61.00 kDa

function: malate utilization

product: malate dehydrogenase (decarboxylating)

essential: no

ec: 1.1.1.38

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources]

Gene

Coordinates on the chromosome (coding sequence): 3,056,849 -> 3,058,549

The protein

Catalyzed reaction/ biological activity

• (S)-malate NAD = pyruvate CO₂ NADH (according to Swiss-Prot) malate --> pyruvate

Protein family

• malic enzymes family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|MaeA] [protein|search|YtsJ] [protein|search|MleA]

Structure

• [PDB|1LLQ] (from ''A. suum'', 40% identity)

Expression and Regulation

Operon

• ''[protein|search|malS]'' [Pubmed|9387221]

Biological materials

Mutant

• GP1142 (spc) available in [SW|Stülke] lab

References

• 9387221,16788182,12949160,23136871,22740702