SubtiBank SubtiBank
flhF [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
SAVE THE DATE! 21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.

flhF [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

signal recognition particle-like GTPase, placement and assembly of flagella, control of basal body position
locus
BSU16400
pI
8.72
mw
40.00 kDa
function
placement and assembly of polar flagella
product
signal recognition particle-like GTPase
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.2|Flagellar proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|motility and chemotaxis], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon], [SW|DegU regulon], [SW|SigD regulon], [SW|Spo0A regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • GTPase activity [Pubmed|22056770]
  • placement of the first flagellar protein, [protein|search|FliF] [Pubmed|22056770]
  • Protein family

  • GTP-binding [protein|search|SRP] family (according to Swiss-Prot)
  • Effectors of protein activity

  • interaction with [protein|search|FlhG] activates the GTPase activity of [protein|search|FlhF] [Pubmed|22056770]
  • Structure

  • [PDB|2PX3] (complexed with GTP-Mg2+) [Pubmed|17699634]
  • [PDB|3SYN] (complex with its activator [protein|search|YlxH]) [Pubmed|22056770]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • [SW|Interactions]

  • [protein|search|FlhG]-[protein|search|FlhF] ([protein|search|FlhG] binds the GTP-bound homodimer of [protein|search|FlhF]) [Pubmed|22056770]
  • Expression and Regulation

    Operon

  • part of the [[fla-che operon]]
  • ''[protein|search|flgB]-[protein|search|flgC]-[protein|search|fliE]-[protein|search|fliF]-[protein|search|fliG]-[protein|search|fliH]-[protein|search|fliI]-[protein|search|fliJ]-[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|9657996,8157612,15175317]
  • ''[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|20233303]
  • [SW|Sigma factor]

  • ''[protein|search|flgB]'': [protein|search|SigA] [Pubmed|9657996], [protein|search|SigD] [Pubmed|9657996]
  • ''[protein|search|ylxF]'': [protein|search|SigD] [Pubmed|20233303]
  • Regulation

  • see [[fla-che operon]]
  • Regulatory mechanism

  • see [[fla-che operon]]
  • Biological materials

    Mutant

  • 1A925 ( ''flhF''::''cat''), [Pubmed|15317803], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A925&Search=1A925 BGSC]
  • References

    Reviews

  • 26195616
  • Original Publications

  • 1447978,17699634,17850253,15317803,14651647,9657996,8157612,15175317,22056770,23190039,24386445