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splB [2017-02-27 15:02:04]
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splB [2017-02-27 15:02:04]

spore photoproduct lyase, radical SAM enzyme
Locus
BSU13930
Isoelectric point
8.00
Molecular weight
39.00 kDa
Protein length
342 aa Sequence Blast
Gene length
1026 bp Sequence Blast
Function
protection of spore DNA against photodamage
Product
spore photoproduct lyase
Essential
no
Synonyms
spl
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Genetics → DNA repair/ recombination
  • Information processing → Genetics → DNA repair/ recombination → Other proteins
  • Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other

    • This gene is a member of the following regulons

  • SigG regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,461,770 -> 1,462,798

    The protein

    Catalyzed reaction/ biological activity

  • repairs a special thymine dimer (5-thyminyl-5,6-dihydrothymine), which is commonly called spore photoproduct at the early germination phase

    • Cofactors

  • contains a [4Fe-4S] cluster, uses the [4Fe-4S] cluster to reduce SAM

    • Structure

  • 4FHC (SplB from Geobacillus thermodenitrificans, 72% identity, 90% similarity) PubMed
    • Expression and Regulation
    [[this]]

    Biological materials

    Mutant

  • BP130 (del splB::spc), available in Fabian Commichau's lab

    • References

    Reviews

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    Structure of the spore photoproduct lesion in DNA

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    Original publications

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