A/G-specific adenine glycosylase, error prevention oxidized guanine system, releases adenines from 8-oxo-G:A mismatches
product
A/G-specific adenine glycosylase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.5|Oxidized guanine (GO) DNA repair system][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination]This gene is a member of the following [SW|regulons]
[SW|YfhP regulon]Gene
Coordinates on the chromosome (coding sequence)
935,656 -> 936,765
Phenotypes of a mutant
strongly reduced stationary phase mutagenesis [Pubmed|27399782]increased susceptibility to Cr(VI) due to the accumulation of oxidative DNA damage [Pubmed|24973075]The protein
Catalyzed reaction/ biological activity
releases adenines from 8-oxo-G:A mismatchesStructure
[PDB|1RRS] (complex with DNA, Geobacillus stearothermophilus)Expression and Regulation
Operon
''[protein|search|mutY]-[protein|search|fabL]-[protein|search|sspE]'' [Pubmed|10463184][SW|Sigma factor]
[protein|search|SigA] [Pubmed|10463184][protein|search|SigG] [Pubmed|1900507]Regulation
expression is constitutive throughout growth [Pubmed|20971907]expression is fivefold increased in a ''[protein|search|mutS]-[protein|search|mutL]'' mutant [Pubmed|20971907][protein|search|YfhP] may act as a negative transcription regulator of the ''[protein|search|mutY]-[protein|search|fabL]-[protein|search|sspE]'' operon during exponential growth [Pubmed|10463184]References
Reviews
Original publications
10463184,19011023,20971907,24973075,25326311,25995449,27399782 
