SubtiBank SubtiBank
rodA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

rodA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

SEDS family peptidoglycan glycosyltransferase, control of cell shape and elongation
locus
BSU38120
pI
8.00
mw
43.00 kDa
function
control of cell shape and elongation
product
SEDS family peptidoglycan glycosyltransferase
essential
yes
synonyms
ywcF, ipa-42d

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|cell shape], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigM regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,912,332 -> 3,913,513

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • CRISPRi knockdown mutant has a terminal phenotype of severe lysis [Pubmed|27238023]
  • The protein

    Catalyzed reaction/ biological activity

  • principal peptidoglycan glycosyltransferase of the [SW|elongasome] [Pubmed|27525505]
  • Protein family

  • [SW|FtsW]/[SW|RodA]/[SW|SpoVE] family (according to Swiss-Prot)
  • [SW|SEDS proteins] (shape, elongation, division, and sporulation)
  • Paralogous protein(s)

  • [protein|search|FtsW], [SW|SpoVE]
  • [SW|Localization]

  • integral membrane protein [Pubmed|21636744]
  • forms circumferentially moving patches [Pubmed|21636744]
  • localization depends on [SW|MreB] [SW|26679002]
  • [SW|Interactions]

  • part of the [SW|elongasome] [Pubmed|21636744,21636745]
  • Expression and Regulation

    Operon

  • ''rodA'' [Pubmed|9353933]
  • [SW|Sigma factor]

  • [protein|search|SigM] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 Pubmed]
  • Biological materials

    Mutant

  • xylose-inducible CRISPRi knockdown mutant BEC38120 is available from the [http://subtiwiki.uni-goettingen.de/wiki/index.php/Daniel_R._Zeigler BGSC]
  • Labs working on this gene/protein

  • [SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]
  • [SW|David Rudner], Harvard Medical School, MA, USA [http://rudnerlab.med.harvard.edu/ homepage]
  • References

    Reviews

  • 26679002
  • Original Publications

  • 27525505, 27238023, 9622350,21636744,21636745,17981970