negative regulator of FtsZ ring formation
function
control of FtsZ ring formation
product
FtsZ-interacting protein
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell division], [SW|membrane proteins]Gene
Coordinates on the chromosome (coding sequence)
3,029,729 -> 3,031,417
Phenotypes of a mutant
altered localization of [protein|search|FtsZ] and [ponA|search|PBP1] [Pubmed|25403286]growth defects, elongated cells [Pubmed|25403286]the ''[protein|search|ezrA]'' mutation is synthetically lethal with a ''[protein|search|sepF]'' mutation [Pubmed|24218584]a ''[protein|search|yvcL] [protein|search|ezrA]'' double mutant grows poorly, and the cells are filamentous [Pubmed|24097947]a ''[protein|search|zapA] [protein|search|ezrA]'' double mutant forms filamentous cells [Pubmed|16420366]depletion of ''[protein|search|pdhA]'' and deletion of ''[protein|search|ezrA]'' have a strong synthetic defect in [SW|cell division] [Pubmed|24825009]The protein
Catalyzed reaction/ biological activity
inhibits [protein|search|FtsZ] polymerization [Pubmed|25403286]recruits [ponA|search|PBP1] to the division septum [Pubmed|25403286]activates [protein|search|PrkC] [Pubmed|25845974]Protein family
ezrA family (according to Swiss-Prot)Effectors of protein activity
degradation of [protein|search|EzrA] involves [protein|search|FtsH] [Pubmed|24222488]Structure
[PDB|4UXV] (the 60 kDa cytoplasmic domain) [Pubmed|25403286][SW|Localization]
membrane associated [Pubmed|18763711]1 transmembrane domain at the N-terminus [Pubmed|25403286][SW|Interactions]
[protein|search|EzrA]-[protein|search|UgtP] [Pubmed|17662947][protein|search|FtsZ]-[protein|search|EzrA] [Pubmed|25403286,10449747][protein|search|EzrA]-[protein|search|GpsB] [Pubmed|18363795][protein|search|EzrA]-[protein|search|PonA] [Pubmed|18363795]Expression and Regulation
Operon
''[protein|search|ezrA]'' [Pubmed|9387221][SW|Sigma factor]
[protein|search|SigA] [Pubmed|15317798]Regulation
constitutively expressed [Pubmed|23701187]Additional information
degradation of [protein|search|EzrA] involves [protein|search|FtsH] [PubMed|24222488]Biological materials
Mutant
1A805 ( ''ezrA''::''kan''), [Pubmed|15101985], available at [http://bgsc.org BGSC]1A1279 (''ezrA''::''spec''), [Pubmed|10449747], available at [http://bgsc.org BGSC]1A1280 (''ezrA-gfp''), [Pubmed|10449747], available at [http://bgsc.org BGSC]References
Reviews
Original Publications
10449747,16420366,15317782,16549676,17662947,12368265,18363795,9387221,15317798,19429628,18763711,21401734,24222488,23701187,17718511,24218584,24097947,24825009,25068683,25403286,25845974,25954268 
