pheT [Mon May 16 2016 16:15:13 GMT+0200 (CEST)]

phenylalanyl-tRNA synthetase (beta subunit)

locus: BSU28630

pI: 4.00

mw: 87.00 kDa

function: translation

product: phenylalanyl-tRNA synthetase (beta subunit)

essential: yes

ec: 6.1.1.20

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|translation], [SW|essential genes], [SW|most abundant proteins]

This gene is a member of the following [SW|regulons]

• [SW|T-box]

Gene

Coordinates on the chromosome (coding sequence): 2,927,008 -> 2,929,422

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP L-phenylalanine tRNA(Phe) = AMP diphosphate L-phenylalanyl-tRNA(Phe) (according to Swiss-Prot)

Protein family

• Type 1 subfamily (according to Swiss-Prot)

Structure

• [PDB|1PYS] (from ''Thermus thermophilus hb8 mutant'', 37% identity, 56% similarity) [Pubmed|7664121]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|PheS]-[protein|search|PheT]

Expression and Regulation

Operon

• ''[protein|search|pheS]-[protein|search|pheT]'' [Pubmed|2127701]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|2127701]

Regulation

• induced by phenylalanine limitation ([protein|search|T-box]) [Pubmed|19258532]

Regulatory mechanism

• [protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]

Additional information

• belongs to the 100 [[most abundant proteins]] [PubMed|15378759]

References

• 19258532,2127701,15378759