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gyrA [2017-12-06 13:21:43]
function
DNA supercoiling, initation of replication cycle and DNA elongation
product
DNA gyrase (subunit A)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
6,994 → 9,459
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to Swiss-Prot)Protein family
topoisomerase gyrA/parC subunit family (according to Swiss-Prot)Paralogous protein(s)
[protein|9075DD0CC0B8554F0379732453665F43C70EFC26|ParC]Structure
[PDB|4DDQ] (DNA gyrase A-subunit lacking the C-terminal DNA-wrapping domains) [Pubmed|23602808][SW|Localization]
Nucleoid (Homogeneous) [Pubmed|16479537]nucleoid-associated in actively growing cells [Pubmed|9539793]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]Labs working on this gene/protein
[SW|Dagmar Klostermeier], University of Münster, Germany, [http://www.biozentrum.unibas.ch/klostermeier/index.html homepage]References
16479537,17981983,9539793,2987848,19666507,17320901,23475963,23602808,20870749,24563461,27557712,27793284