SubtiBank SubtiBank
gyrA
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gyrA

DNA gyrase (subunit A)
locus
BSU_00070
pI
5.22
mw
91.91 kDa
protein length
821 aa Sequence Blast
gene length
2466 bp Sequence Blast
function
DNA supercoiling, control of [category|SW 3.1.1|replication] initiation
product
DNA gyrase (subunit A)
essential
yes
ec
5.99.1.3
synonyms
nalA

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    6,994 → 9,459

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to UniProt)
  • decreases [protein|6740108089F13116F200C15F35C2E7561E990FEB|DnaA] association with the oriC and inhibits [category|SW 3.1.1|replication] initiation [pubmed|29396913]
  • Protein family

  • Topoisomerase IIA [protein|B207C7328177924B16F1C606F667BEADF12CA069|GyrA]/[protein|9075DD0CC0B8554F0379732453665F43C70EFC26|ParC] subunit family (together with [protein|9075DD0CC0B8554F0379732453665F43C70EFC26|ParC]) (according to UniProt)
  • Paralogous protein(s)

  • [protein|9075DD0CC0B8554F0379732453665F43C70EFC26|ParC]
  • Structure

  • [PDB|4DDQ] (DNA gyrase A-subunit lacking the C-terminal DNA-wrapping domains) [Pubmed|23602808]
  • [SW|Localization]

  • Nucleoid (Homogeneous) [Pubmed|16479537]
  • nucleoid-associated in actively growing cells [Pubmed|9539793]
  • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]
  • Expression and Regulation

    Operons

    genes
    [gene|FB1C21A94697E5B9D29C0F3B9C9F36E57BCBD237|yaaA]-[gene|EBE03AEC7EC594A3115A7A72194BDFF300AA0BFA|recF]-[gene|CBC76FB453569550F14FE5015C05D45985C04979|remB]-[gene|AA42910B71348EFEA4165CFFCEF1E497897B9DDC|gyrB]-[gene|B207C7328177924B16F1C606F667BEADF12CA069|gyrA]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|2987848], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • view in new tab

    labs

  • [SW|Dagmar Klostermeier], University of Münster, Germany, [http://www.biozentrum.unibas.ch/klostermeier/index.html homepage]
  • References

    Reviews

  • 16936698
  • Original publications

  • 16479537,17981983,9539793,2987848,19666507,17320901,23475963,23602808,20870749,24563461,27557712,27793284,12767818,6282812,29396913,8940171,7590259,10944214,6248518,6243420,225110,17334374,30457554,30517674