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acoA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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acoA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)
locus
BSU08060
pI
4.91
mw
35.00 kDa
function
acetoin utilization
product
acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)
essential
no
synonyms
yfjK
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.2|Utilization of acetoin]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources], [SW|sporulation proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|AcoR regulon], [SW|CcpA regulon], [SW|SigL regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    879,002 -> 880,003

    The protein

    Paralogous protein(s)

  • [SW|BkdAA], [protein|search|PdhA]

    • [SW|Localization]

  • cytoplasm (homogeneous) [Pubmed|16479537]

    • [SW|Interactions]

  • ([protein|search|AcoA]-[protein|search|AcoB])-[protein|search|AcoC]-[protein|search|AcoL]

    • Expression and Regulation

    Operon

  • ''[protein|search|acoA]-[protein|search|acoB]-[protein|search|acoC]-[protein|search|acoL]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/11274109 PubMed]

    • [SW|Sigma factor]

  • [protein|search|SigL] [http://www.ncbi.nlm.nih.gov/sites/entrez/11274109 PubMed]

    • Regulation

  • repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]
  • induced by acetoin ([protein|search|AcoR]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11274109 PubMed]
  • induced under anaerobic conditions ([protein|search|Fnr]) [Pubmed|16428414]

    • Regulatory mechanism

  • [protein|search|CcpA]: transcription repression [Pubmed|10666464]
  • [protein|search|AcoR]: transcription activation (interaction with [protein|search|SigL]-containing [SW|RNA polymerase]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11274109 PubMed]
  • [protein|search|Fnr]: indirect positive regulation via [protein|search|NarG]-[protein|search|NarH]-[protein|search|NarJ]-[protein|search|NarI] [Pubmed|16428414]

    • Additional information

  • the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
  • the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]

    • Labs working on this gene/protein

  • [SW|Michel Debarbouille], Pasteur Institute, Paris, France [http://www.pasteur.fr/ip/easysite/go/03b-00000m-0ob/recherche/departements-scientifiques/microbiologie/unites-et-groupes/unite-de-biologie-des-bacteries-pathogenes-a-gram-positif/les-membres-de-l-equipe Homepage]

    • References

  • 22900538,21815947,11274109,10368162,10666464,12884008,16479537,11274109,16428414