priA [Mon Oct 10 2016 20:03:16 GMT+0200 (CEST)]

primosomal replication factor Y, part of the replisome

locus: BSU15710

pI: 8.00

mw: 91.00 kDa

function: DNA replication initiation

product: primosomal replication factor Y

essential: yes

ec: 3.6.4.-

synonyms: yloJ

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|DNA replication], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence): 1,644,068 -> 1,646,485

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Protein family

• helicase C-terminal domain (according to Swiss-Prot)

Structure

• [PDB|4NL4] (from ''Klebsiella pneumoniae'', 38% identity) [Pubmed|24379377]

[SW|Interactions]

• [protein|search|DnaD]-[protein|search|PriA] [Pubmed|11585815], [protein|search|DnaB]-[protein|search|PriA] [Pubmed|11585815]
• part of the [SW|replisome]: [protein|search|PolC]-[protein|search|HolA]-[protein|search|HolB]-[protein|search|DnaX]-[protein|search|DnaN]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|SsbA]-[protein|search|DnaE]-[protein|search|PriA]-[protein|search|DnaB] [Pubmed|20122408]

Expression and Regulation

Additional information

• the mRNA is cleaved by [rnc|search|RNase III] [PubMed|26883633]

References

• 17853894,20122408,11585815,10572298,24379377,26883633