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phrF
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phrF

response regulator aspartate phosphatase (RapF) regulator, antagonizes the RapF-ComA interaction
locus
BSU_37470
pI
10.24
mw
4.07 kDa
protein length
39 aa Sequence Blast
gene length
120 bp Sequence Blast
function
control of ComA activity
product
phosphatase (RapF) regulator
essential
no
synonyms
ywhI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
  • [category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides]

    • Gene

    Coordinates
    3,847,130 → 3,847,249

    The protein

    Catalyzed reaction/ biological activity

  • binds to [protein|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|RapF], this results in the inability of [protein|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|RapF] to interact with [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA] [Pubmed|15968044]

    • Protein family

  • [SW|phr family] (according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|rapF]-[gene|AEBEDF43C56A9A54716D781D062067B69818FAF4|phrF]
    description
    [Pubmed|11466295]

    sigma factors

  • [protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH]: sigma factor, [Pubmed|11466295], in [regulon|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH regulon]

    • regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|12850135], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]
  • [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]: activation, [Pubmed|15968044], in [regulon|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA regulon]

    • regulation

  • PhrF accumulates at high cell density
    • view in new tab

    genes
    [gene|AEBEDF43C56A9A54716D781D062067B69818FAF4|phrF]
    description
    [Pubmed|11466295]

    regulation

  • PhrF accumulates at high cell density
    • view in new tab

    Biological materials

    Mutant

  • BKE37470 (Δ[gene|AEBEDF43C56A9A54716D781D062067B69818FAF4|phrF]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE37470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAGAGCCAGACAAGAGAGTA, downstream forward: _UP4_TAACCGCCGTCCATCGGCGG
  • BKK37470 (Δ[gene|AEBEDF43C56A9A54716D781D062067B69818FAF4|phrF]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK37470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAGAGCCAGACAAGAGAGTA, downstream forward: _UP4_TAACCGCCGTCCATCGGCGG

    • References

  • 16816200,15968044,11466295,16091051,22215984