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liaH [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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liaH [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

similar to phage shock protein, resistance against oxidative stress and cell wall antibiotics (such as daptamycin)
locus
BSU33120
pI
6.00
mw
25.00 kDa
function
resistance against oxidative stress and cell wall antibiotics
product
unknown
essential
no
synonyms
yvqH

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [SW|Categories] containing this gene/protein

  • [SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics]
  • This gene is a member of the following [SW|regulons]

  • [SW|LiaR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,397,846 -> 3,398,523

    The protein

    Protein family

  • pspA/IM30 family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|PspA]
  • [SW|Localization]

  • variable (spotty) protein [Pubmed|16479537]
  • throughout the cytoplasm under non-inducing conditions [Pubmed|24666271]
  • co-localizes with [protein|search|LiaI] in distinct static spots at the cytoplasma membrane under stress conditions [Pubmed|24666271]
  • [SW|Interactions]

  • forms large oligomeric rings with a nine-fold rotational symmetry [Pubmed|20639339]
  • [protein|search|LiaI]-[protein|search|LiaH] [Pubmed|24666271]
  • Expression and Regulation

    Operon

  • ''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|14651641]
  • ''[protein|search|liaI]-[protein|search|liaH]'' [Pubmed|20639339]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|15273097]
  • Regulation

  • induced by bacitracin and rhamnolipids ([protein|search|LiaR]) [Pubmed|16816187,22092710]
  • induced by daptomycin [Pubmed|27791134]
  • repressed during logarithmic growth ([protein|search|AbrB]) [PubMed|15101989,17660417], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]
  • Regulatory mechanism

  • [protein|search|LiaR]: transcription activation [Pubmed|16816187]
  • References

    Reviews

  • 27344142
  • Original publications

  • 19164152,15273097,20057163,16816187,15101989,17660417,16816187,20639339,16479537,20817675,22092710,24666271,27791134