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rsbT [Mon Aug 31 2015 13:52:36 GMT+0200 (CEST)]
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rsbT [Mon Aug 31 2015 13:52:36 GMT+0200 (CEST)]

PP2C activator, protein serine kinase, phosphorylates RsbS and RsbR, part of the stressosome
locus
BSU04690
pI
6.00
mw
14.00 kDa
function
control of SigB activity
product
PP2C activator, protein serine kinase
essential
no
synonyms
ycxT

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [SW|Categories] containing this gene/protein

  • [SW|protein modification], [SW|sigma factors and their control]
  • Gene

    Coordinates on the chromosome (coding sequence)
    520,606 -> 521,007

    The protein

    Catalyzed reaction/ biological activity

  • phosphorylation of [protein|search|RsbR], [SW|RsbRB], [SW|RsbRC], and [SW|RsbRD] [Pubmed|21362065]
  • Effectors of protein activity

  • phosphorylated [protein|search|RsbR] activates the kinase activity of [protein|search|RsbT] [Pubmed|23320651]
  • activity is stimulated by light in a [protein|search|YtvA]-dependent manner [Pubmed|23416074]
  • Structure

  • [PDB|3VY9] (complete stressosome)
  • [SW|Interactions]

  • [protein|search|RsbS]-[protein|search|RsbT] [Pubmed|16321960]
  • [protein|search|RsbR]-[protein|search|RsbT] [Pubmed|21362065]
  • [SW|RsbRB]-[protein|search|RsbT] [Pubmed|21362065]
  • [SW|RsbRC]-[protein|search|RsbT] [Pubmed|21362065]
  • [SW|RsbRD]-[protein|search|RsbT] [Pubmed|21362065]
  • [protein|search|RsbT]-[protein|search|RsbU]
  • component of the [SW|stressosome]
  • Expression and Regulation

    Operon

  • ''[protein|search|rsbR]-[protein|search|rsbS]-[protein|search|rsbT]-[protein|search|rsbU]-[protein|search|rsbV]-[protein|search|rsbW]-[protein|search|sigB]-[protein|search|rsbX]'' [Pubmed|8002610]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8002610]
  • Regulation

  • constitutively expressed [Pubmed|20019076]
  • Additional information

  • [protein|search|RsbT] is synthesized at the same rate as [protein|search|RsbRA] and [protein|search|RsbS], however, the [protein|search|RsbT] level in growing 'B. subtilis' is only 10% that of [protein|search|RsbRA], suggesting that the protein is unstable [PubMed|20019076].
  • Labs working on this gene/protein

  • [SW|Bill Haldenwang], San Antonio, USA
  • [SW|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
  • [SW|Rick Lewis], Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/r.lewis homepage]
  • References

    Reviews

  • 19704888,16319496,20658979
  • Original Articles

  • 8682789,8002610,8682769,9658013,17303566,9786195,15090521,10781545,15583165,8824586,10329124,16321960,8808936,15312768,11244072,15342582,20019076,12499568,12950928,16321960,8955331,18832644,24599254,23407164,23320651,21362065,23416074,21979936