adenylosuccinate synthetase
function
purine biosynthesis
product
adenylosuccinate synthetase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|phosphoproteins], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|PurR regulon]Gene
Coordinates on the chromosome (coding sequence)
4,155,433 -> 4,156,725
The protein
Catalyzed reaction/ biological activity
GTP IMP L-aspartate = GDP phosphate N(6)-(1,2-dicarboxyethyl)-AMP (according to Swiss-Prot) Protein family
adenylosuccinate synthetase family (according to Swiss-Prot)Modification
phosphorylated on Arg-97 [Pubmed|22517742]Structure
[PDB|1KJX] (from ''Escherichia coli k12'', 46% identity, 64% similarity) [Pubmed|11741996][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''purA'' [Pubmed|1312531][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1312531]Regulation
expression activated by glucose (4.9 fold) ([protein|search|CcpA]) [Pubmed|12850135]repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]Regulatory mechanism
[protein|search|PurR]: transcription repression [Pubmed|7638212]Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]References
1722815,1312531,7638212,12850135,21424839,22517742,15378759 
