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spoIVFA [Mon Aug 31 2015 13:56:02 GMT+0200 (CEST)]
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spoIVFA [Mon Aug 31 2015 13:56:02 GMT+0200 (CEST)]

inhibitor of SpoIVFB metalloprotease
locus
BSU27980
pI
7.29
mw
29.00 kDa
function
control of SigK activation
product
inhibitor of SpoIVFB metalloprotease
essential
no
synonyms
bofB, spoVL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
    • syns
    bofB, spoVL

    [SW|Categories] containing this gene/protein

  • [SW|sigma factors and their control], [SW|sporulation proteins], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigE regulon]

    • The protein

    [SW|Domains]

  • the ectodomain of [SW|SpoIVFA] is cleaved off by [SW|SpoIVB] (first cleavage) [Pubmed|24243021]
  • the domains that inhibits [SW|SpoIVFB] is cleaved off by [protein|search|CtpB] (second cleavage) [Pubmed|24243021]

    • [SW|Localization]

  • mother cell membrane [Pubmed|24243021]
  • integral membrane protein [Pubmed|11959848]

    • [SW|Interactions]

  • [SW|SpoIVFB]-[SW|SpoIVFA], to facilitate the recruitment of [protein|search|BofA] to [SW|SpoIVFB] [Pubmed|11959848]
  • [protein|search|BofA]-[SW|SpoIVFA] [Pubmed|11959848]
  • [SW|SpoIVB]-[SW|SpoIVFA] [Pubmed|24243021]
  • [protein|search|CtpB]-[SW|SpoIVFA] [Pubmed|24243021]

    • Additional information

  • the ectodomain of [SW|SpoIVFA] is cleaved off by [SW|SpoIVB] (first cleavage) [Pubmed|24243021]
  • the domains that inhibits [SW|SpoIVFB] is cleaved off by [protein|search|CtpB] (second cleavage) {{PubMed|24243021}

    • Expression and Regulation

    Operon

  • ''[SW|spoIVFA]-[SW|spoIVFB]'' [Pubmed|1942049]
  • ''[SW|spoIVFA]-[SW|spoIVFB]-[protein|search|rplU]-[protein|search|prp]-[protein|search|rpmA]'' [Pubmed|22383849]

    • [SW|Sigma factor]

  • [protein|search|SigE] [Pubmed|15699190,1942049]

    • Regulation

  • expressed early during sporulation in the mother cell ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|15699190,1942049,15383836]

    • Regulatory mechanism

  • [SW|SpoIIID]: transcription repression [Pubmed|15383836]

    • References

  • 11959848,9501233,1577688,15292188,2115401,12940997,9078383,15752199,16818230,15699190,1942049,15383836,17557826,24243021,22383849