SubtiBank SubtiBank
mrpB
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mrpB

Na+/H+ antiporter subunit, multiple resistance and pH homeostasis
locus
BSU31610
pI
4.91
mw
15.15 kDa
protein length
143 aa Sequence Blast
gene length
432 bp Sequence Blast
function
sodium export
product
Na+/H+ antiporter subunit
essential
yes
synonyms
yufU

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.2|Sodium uptake/ export]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    3,248,996 3,249,427

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Structure

  • [PDB|6CFW] (from Pyrococcus furiosus, corresponds to aa 1 ... 104, 31% identity) [pubmed|29754813]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]-[gene|AAB15E7E3E3701AA3159370B85C151994244BA5B|mrpB]-[gene|D921139B18A665E9BB177C973FCF050A4BFFF97F|mrpC]-[gene|051D9BCC0CB05E39ED5825BB9BA77B8228EA055D|mrpD]-[gene|BF233467FAF95EEEE12A0D36C543DB357D8879EA|mrpE]-[gene|5CA2EA2D60FE4696903C16698C8329A20CBEBF72|mrpF]-[gene|B28796716C7E6C924F55176453DDBF9ADD0EF755|mrpG]
    description
    [Pubmed|9274030,10198001]
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    Biological materials

    Mutant

  • MGNA-B558 (yufU::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1557 NBRP B. subtilis, Japan]
  • SM-GN9 (mrpB-spc), available in [SW|Anne Galinier]'s and [SW|Boris Görke]'s labs
  • References

    Reviews

  • 29218041
  • Original publications

  • 11004162,9274030,10198001,19389778,17693497,18408029,29754813