gerM [Fri Jul 15 2016 15:33:37 GMT+0200 (CEST)]

lipoprotein, germination (cortex hydrolysis) and sporulation, required for the assembly of the basal platform of the SpoIIIA-SpoIIQ transenvelope complex during sporulation

locus: BSU28380

pI: 4.00

mw: 39.00 kDa

function: germination (cortex hydrolysis) and sporulation

product: SpoIIQ recruitment factor

essential: no

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.4|Germination] → [category|SW 4.2.4.2|Additional germination proteins]

[SW|Categories] containing this gene/protein

• [SW|germination], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigE regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,902,002 -> 2,903,102

Phenotypes of a mutant

• inactivation of ''[SW|gerM]'' reduces sporulation efficiency to 0.3% that of wild type cells [Pubmed|26735940]

The protein

Catalyzed reaction/ biological activity

• required for the assembly of the basal platform of the [SW|SpoIIIA]-[SW|SpoIIQ] transenvelope complex during [SW|sporulation] [Pubmed|27381174]
• required for the recruitment of [SW|SpoIIQ] to the septal membranes on the forespore side [Pubmed|27381174]

[SW|Localization]

• outer forespore membrane, localization depends on [SW|SpoIIIA] and [SW|SpoIIQ] [Pubmed|27381174]

[SW|Interactions]

• lipoprotein, membrane [Pubmed|27381174]

Expression and Regulation

Operon

• ''gerM'' [Pubmed|8969504]

[SW|Sigma factor]

• [protein|search|SigE] [Pubmed|8969504,15699190]

Regulation

• expressed early during sporulation in the mother cell ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|8969504,15699190,15383836]
• repressed by casamino acids [Pubmed|12107147]

Regulatory mechanism

• [SW|SpoIIID]: transcription repression [Pubmed|15383836]

References

• 7926687,15699190,12107147,8969504,15699190,15383836,18562273,26735940,27381174