SubtiBank SubtiBank
gyrB [Mon Oct 31 2016 10:40:43 GMT+0100 (CET)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

gyrB [Mon Oct 31 2016 10:40:43 GMT+0100 (CET)]

DNA gyrase (subunit B)
locus
BSU00060
pI
5.00
mw
71.00 kDa
function
DNA supercoiling,
initation of replication cycle and DNA elongation
product
DNA gyrase (subunit B)
essential
yes
ec
5.99.1.3
synonyms
novA

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA condensation/ segregation], [SW|essential genes]
  • Gene

    Coordinates on the chromosome (coding sequence)
    4,867 -> 6,783

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to Swiss-Prot)
  • Protein family

  • type II topoisomerase family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|ParE]
  • [SW|Domains]

  • [SW|TOPRIM domain] (aa 422-536) [Pubmed|9722641]
  • Modification

  • phosphorylated on Ser-400 [Pubmed|20509597]
  • Structure

  • [PDB|4I3H] (from ''Streptococcus pneumoniae'', 55% identity) [Pubmed|23965305]
  • [SW|Localization]

  • nucleoid-associated in actively growing cells [Pubmed|9539793]
  • [SW|Interactions]

  • [protein|search|GyrA]-[protein|search|GyrB]
  • Expression and Regulation

    Operon

  • ''[protein|search|yaaA]-[protein|search|recF]-[protein|search|yaaB]-[protein|search|gyrB]'' [Pubmed|2987848]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|2987848]
  • Additional information

  • GyrB is subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]
  • Labs working on this gene/protein

  • [SW|Dagmar Klostermeier], University of Münster, Germany [http://www.biozentrum.unibas.ch/klostermeier/index.html homepage]
  • References

  • 17981983,9539793,2987848,19666507,17320901,20509597,23475963,23965305,9722641,27557712