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ponA [Tue May 03 2016 20:08:16 GMT+0200 (CEST)]
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ponA [Tue May 03 2016 20:08:16 GMT+0200 (CEST)]

class A penicillin-binding protein 1A/1B, contributes to cell elongation and cell division
locus
BSU22320
pI
4.00
mw
99.00 kDa
function
bifunctional glucosyltransferase/ transpeptidase
product
penicillin-binding protein 1A/1B
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins]
  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|membrane proteins], [SW|penicillin-binding proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigM regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,341,444 -> 2,344,188

    Phenotypes of a mutant

  • prevents bulging of the cells when grown at low Mg(2 ) concentrations, suppresses the lethal effect of a ''[protein|search|mreB]'' mutation [Pubmed|19192185]
  • deletion of ''ponA'' restores growth and normal shape of a ''[protein|search|yvcK]'' mutant on gluconeogenic carbon sources [Pubmed|21320184]
  • The protein

    [SW|Localization]

  • membrane associated [Pubmed|18763711]
  • localizes to the spore septum during sporulation [Pubmed|15758244,15262952]
  • localizes to the vegetative septum [Pubmed|15262952], this depends on [protein|search|YvcK] [Pubmed|21320184]
  • [SW|Interactions]

  • [protein|search|EzrA]-[protein|search|PonA] [Pubmed|18363795]
  • [protein|search|GpsB]-[protein|search|PonA] [Pubmed|18363795]
  • [protein|search|MreB]-[protein|search|PonA] [Pubmed|19192185]
  • Expression and Regulation

    Operon

  • ''[protein|search|recU]-[protein|search|ponA]'' [Pubmed|7814321]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|22211522], [protein|search|SigM] [Pubmed|18179421]
  • Regulation

  • constitutive during vegetative growth [Pubmed|15758244]
  • Biological materials

    two-hybrid system

  • ''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jeff Errington] lab
  • Labs working on this gene/protein

  • [SW|Jeff Errington], Newcastle University, UK [http://www.ncl.ac.uk/camb/staff/profile/jeff.errington homepage]
  • References

    Reviews

  • 21371139
  • Original publications

  • 8606187,15262952,9721295,10322023,19192185,7814321,18363795,14731276,21320184,18763711,19192185,18179421,23531131,18363795