purR [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

transcription repressor of the pur operon

Locus: BSU00470

Isoelectric point: 5.77

Molecular weight: 31.00 kDa

Function: regulation of purine biosynthesis

Product: transcription repressor of the pur operon

Essential: no

Synonyms: yabI

Genomic Context

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Categories containing this gene/protein

• Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Biosynthesis/ acquisition of purine nucleotides
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other

Syns: yabI

Categories containing this gene/protein

• biosynthesis/ acquisition of nucleotides, transcription factors and their control

This gene is a member of the following regulons

• PurR regulon

The protein

Protein family

• purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)

Effectors of protein activity

• PRPP acts as inducer, binding results in release of PurR from the operator PubMed

Structure

• 1O57, 1O57 NCBI PubMed

Interactions

• PurR-Prs

Additional information

• requires YabJ for in vivo activity

Expression and Regulation

Operon

• purR-yabJ PubMed

Regulation

• negative autoregulation, induction in the presence of PRPP PubMed
• repressed in the presence of purine nucleotides (PurR) PubMed

Regulatory mechanism

• repression by PurR PubMed
• PurR: transcription repression PubMed

References

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