pyrP [Mon Aug 31 2015 13:54:13 GMT+0200 (CEST)]

uracil permease

locus: BSU15480

pI: 9.50

mw: 45.00 kDa

function: uracil transport in/out via proton symport

product: uracil permease

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter]
• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|PyrR regulon]

The protein

Protein family

• xanthine/uracil permease family (according to Swiss-Prot)

[SW|Localization]

• cell membrane [Pubmed|18763711]

Expression and Regulation

Operon

• ''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|1709162]

Regulation

• induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]

Regulatory mechanism

• [protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]

References

• 7868607,8206849,12896995,16133632,1709162,17322189,18763711